This resource may include information that has not been approved by the US Food and Drug Administration. For full prescribing information, including. Fosphenytoin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Medscape – Epilepsy dosing for Cerebyx (fosphenytoin), frequency-based adverse contraindications, pregnancy & lactation schedules, and cost information. be expressed as phenytoin sodium equivalents (PE) when prescribing; There is.
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The precise mechanism by which phenytoin exerts its therapeutic effect has not been established but is thought to involve the voltage-dependent blockade of membrane sodium channels resulting in a reduction in sustained high-frequency neuronal discharges.
Indometacin The metabolism of Fosphenytoin can be decreased when combined with Indomethacin.
Fosphenytoin – DrugBank
Metocurine The therapeutic efficacy of Metocurine can be decreased when used in combination with Fosphenytoin. The amount and concentration of Fosphenytoin is always expressed in terms of mg of phenytoin sodium equivalents mg PE. This study also demonstrated that equimolar doses of IM Fosphenytoin Sodium Injection may be substituted for oral informaation sodium with no dosage adjustments needed when initiating IM fosphenyroin returning to oral therapy. Attention to these details may prevent some Fosphenytoin Sodium Injection fosphwnytoin errors from occurring.
The mechanism of fosphenytoin conversion has not been determined, but phosphatases probably play a major role. Fentanyl The metabolism of Fentanyl can be increased when combined with Fosphenytoin. Ergocalciferol The metabolism of Fosphenytoin can be decreased when combined with Ergocalciferol. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive presxribing or environmental changes capable of reducing membrane sodium gradient.
Plasma Fosphenytoin concentrations following IM administration are lower but more sustained than those following IV administration due to the time required for absorption of Fosphenytoin from the injection site. Doxifluridine The serum concentration of Fosphenytoin can be increased when it is combined with Doxifluridine.
Carboxyamidotriazole The metabolism of Fosphenytoin can be decreased when combined with Carboxyamidotriazole. Individual drug package inserts should be consulted.
Flucloxacillin The metabolism of Fosphenytoin can be increased when combined with Flucloxacillin. Hydroxyzine Hydroxyzine may increase the central nervous system depressant CNS depressant activities of Fosphenytoin.
Lidocaine The metabolism of Fosphenytoin can be decreased when combined with Lidocaine. Plasma concentrations of phenytoin should be monitored during concomitant treatment with nelfinavir. Gilteritinib The metabolism of Fosphenytoin can be decreased when combined with Gilteritinib. Cyclopropane The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Fosphengtoin.
Ciglitazone The metabolism of Fosphenytoin can be decreased when combined with Ciglitazone.
Following Fosphenytoin Sodium Injection administration, it is recommended that phenytoin concentrations not be monitored until conversion to phenytoin is essentially complete. The molecular structure of Fosphenytoin is:. In animal studies, fosphenytoin had no effect on fertility in male rats but decreased fertility in female rats see section 5. No increases in tumor incidence were observed in rats. Fluprednisolone The metabolism of Fosphenytoin can be decreased when combined with Fluprednisolone.
Table 10 displays dosing information for the temporary substitution of oral phenytoin sodium in children. The amount and concentration of fosphenytoin is always expressed in terms of mg of phenytoin sodium equivalents Presribing.
Isosorbide The metabolism of Isosorbide can be increased when combined with Fosphenytoin. A predominantly sensory peripheral polyneuropathy has been observed in patients receiving long-term phenytoin therapy.
FOSPHENYTOIN SODIUM Injection mg PE in 2ml Vial mg PE in 10 ml Vial | Mylan
These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. Phenytoin can substantially reduce the concentrations of delavirdine. There is a risk of potentially fatal respiratory or circulatory depression. Ethosuximide The serum concentration of Fosphenytoin can be increased when it is prdscribing with Ethosuximide.
Lorvotuzumab mertansine The metabolism of Fosphenytoin can be decreased when combined with Lorvotuzumab mertansine. The phosphate load provided by Fosphenytoin Sodium Injection 0.
Package contains 25 vials of NDC Corticotropin The metabolism of Fosphenytoin can be increased when combined with Corticotropin.
There have been a number of reports that have suggested a relationship between phenytoin and the development of lymphadenopathy local or generalizedincluding benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin’s disease. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Clomipramine The metabolism of Clomipramine can be increased when combined with Fosphenytoin.
Midomafetamine The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Midomafetamine. It may also produce lower than normal values for dexamethasone or metyrapone tests. Qualitative and quantitative composition 3. Indinavir The metabolism of Indinavir can be increased when combined with Fosphenytoin.
Dihydralazine The metabolism of Dihydralazine can be increased when combined with Fosphenytoin. Lower or less frequent dosing may be required prescrlbing Clinical Pharmacology In general, IM administration of Fosphenytoin Sodium Injection generates systemic phenytoin concentrations that are similar enough to oral phenytoin sodium to allow essentially interchangeable use.
Bepridil The metabolism of Fosphenytoin can be decreased when combined with Bepridil. Dose reductions or discontinuation should be done gradually. Lomefloxacin The metabolism of Lomefloxacin can be increased when combined with Fosphenytoin.