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The solution or suspension may be prepared in its pure form and administered several times daily. Y” column of Table 1 in an amount effective to treat, prevent or ameliorate the disease or disorder. The albumin fusion proteins of the invention can be used in one or more of the applications described herein 25, and may apply to veterinary medicine.
Fusion proteins albumin of the invention can be used to modulate hemostatic cessation of bleeding or thrombolytic clot dissolving.
Escabiosis, trombiculiasis, infecciones oculares, enfermedades intestinales p. Macromol Sci Rev Macromol Chem In addition to the transformed host cells themselves, the present invention also contemplates a culture of those cells, preferably a monoclonal clonally homogeneous or a culture derived from a monoclonal culture, in a nutrient medium. Such methods are described in many standard laboratory manuals, such as Davis et al.
The albumin fusion proteins of the invention may be useful in the treatment, and cancers other disorders involving angiogenesis. Fusion proteins albumin of the invention may also stimulate healing of mucositis mouth ulcers resulting from chemotherapy and viral infections. Fusion proteins albumin of the invention can be used as adjuvant to enhance ula immune response to a virus, disease or selected symptom group consisting of: The following description should be considered exemplary and using known techniques.
TH2 against a TH1 cellular response.
DiCCA XV – Diccionario del castellano del siglo XV en la Corona de Aragón: Corpus
Preferentemente, el sujeto es un animal, incluyendo, entre otros, animales tales como vacas, cerdos, caballos, pollos, gatos, perros etc.
A wide variety 20 of disorders can result in corneal neovascularization, including for example, corneal infections e. Arterial occlusive diseases include, inter alia, arteriosclerosis, intermittent claudication, carotid stenosis, fibromuscular dysplasias, mesenteric vascular occlusion, Moyamoya disease of, obstruction of the renal arteries, occlusion of retinal artery and thromboangiitis obliterans.
A fusion protein albumin of the invention can also be used to maintain organs before transplantation or 45 for supporting cell culture of primary tissues. The presence and quantity of albumin fusion proteins of the invention can be determined using ELISA, a well known in the art immunoassay.
Las leucopenias incluyen, entre otros, neutropenia y linfocitopenia. A fusion protein albumin of the invention can also be used to prevent skin aging sunburn by stimulating keratinocyte growth. Ischemia Myocardial include, among others, coronary disease such as angina pectoris, coronary aneurysm, coronary arteriosclerosis, coronary thrombosis, coronary vasospasm, myocardial infarction and myocardial stunning ikpetigo Aneurysms include, among others, desiccants, false aneurysms aneurysms, infected aneurysms, ruptured aneurysms, aortic aneurysms, cerebral aneurysms, coronary aneurysms, heart aneurysms, and iliac aneurysms 5.
Examples of immunoassays are described briefly below but not re intended to be limiting. Albumin fusion proteins and beta interferon. The fourth column of Table 2, “Description” provides an overview of a fusion construct 10 albumin and the fifth column, “Expression vector” the vector in which a polynucleotide comprising cloned or, alternatively it is consisting of a nucleic acid molecule weco a fusion protein of albumin given.
Fusion proteins albumin of the invention with a “prolonged” or “extended” half-life exhibit greater therapeutic activity 15 with respect to a pattern that has been subject to the same conditions of storage and impetkgo. Anemia can be caused by excessive bleeding, im;etigo decrease in blood cell production or increased destruction of red blood cells hemolysis.
Fusion proteins albumin to be used to analyze polypeptide levels in a biological sample using classical immunohistological methods known to those skilled in the art see, e. Vibrio cholerae, Mycobacterium leprae, Salmonella typhi, Salmonella paratyphi, Meisseria meningitidis, Streptococcus pneumoniae.
X of the row sedo template DNA.
Many therapeutic proteins are very labile in their unfused state. These compositions can take the form of solutions, suspensions, emulsions, tablets, huemdo, capsules, powders, sustained release formulations and the like release.
Such disorders include, among others, those described in “Biological Activities” section of this document. Other modes of administration are discussed herein.
ES2500918T3 – Albumin fusion proteins and beta interferon – Google Patents
In most cases, this would involve perilimbic corneal injection to “protect” the cornea from the advancing blood vessels. Complications associated with the stress of labor and delivery include premature rupture of the membranes, premature labor, post-term pregnancy, postmaturity, parturition progresses very slowly, fetal distress eg, abnormal heart rhythm fetal or maternalbreathing problems, and abnormal fetal positiondystocia, prolapsed cord, amniotic fluid embolism and abnormal uterine bleeding.
In the art such procedures are known. The immune response can be increased by enhancing an existing immune response, or by initiating a new immune response.
If a fusion protein of albumin actividd 45 exhibits a particular test, probably corresponding to the fusion protein therapeutic protein may be involved in diseases associated with the biological activity.
Pulmonary administration can also be employed by, for example, use of an inhaler or nebulizer, and formulation with an aerosol forming agent Suitable vanadyl complexes include, for example, vanadyl acetylacetonate and vanadyl sulfate of including hydrates such as vanadyl mono- and trihydrates dde vanadyl sulfate.
Having generally described the invention, the same will be more readily understood by reference to the following examples which are provided seo way of illustration and are not intended to be limiting.
The fusion protein labeled albumin humeso accumulate at locations in the body p. A further example of tissue regeneration of non-healing wounds includes pressure ulcers, ulcers associated with vascular insufficiency, surgical and traumatic wounds. The albumin fusion proteins of the invention are used as adjuvant to enhance the specific immune responses of tumor. The radiometal ion associated with the macrocyclic chelator may be 90Y. The fusion constructs may be generated in albumin expression vectors for use in culture systems mammalian cells.
Depending upon the host employed in a recombinant production procedure, the polypeptides of the 15 present invention may be glycosylated or may be non-glycosylated. Por ejemplo, se puede analizar un efecto deseable en un cultivo celular.